CHF/PAH - Basic Pharmacology

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Clues

• Aldosterone antagonist + weak diuretic
• Degrades natriuretic peptides, bradykinin, adrenomed ullin
• Loop diuretic - 'lasts six hours' (Lasix)
• Causes angioedema + cough by ACE-I
• Relatively selective endotholin antagonist
• Neprolysin inhibitor
• i.v. administered BNP analog
• 'Start low-go slow'
• ARB in Entresto
• NT-pro BNP
• Loop diuretic plus inhibits aldosterone
• Positive inotrope + vaqal activity
• Symptom of CHF + PAH (exertion)
• Hydralazine + Nitrates for CHF and HYP
• Synthetic catecholamine, i.v., positive inotropism
• Avoid in 'sick sinus' syndrome
• cGMP stimulator
• IP (prostacyclin) receptor agonist
• Vasoreactivity test (inhaled)
• Pulmonary vasoconstriction (PAH)

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