LUTS: Basic Pharmacology

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Clues

• Inhibits Ach release to relax detrusor
• Action of sildosin
• Inhibits 5-alpha reductase
• Selective for bladder muscarinic (three) receptor
• Relaxes detrusor via beta three receptor
• Most versatile (delivery) antimuscarinic drug for OAB
• Inhibits PDE
• Adverse effect of PDE-I
• Limited crossing of BBB
• Caused by BPH
• Adverse effect of muscarinic antagonist
• Contraindicated with PDE-I
• Treated with "off label" drugs
• Use if antimuscarinic in narrow angle glaucoma
• Prostaglandin
• Adverse effect of tamsulosin
• Acts as agonist at alpha one A receptor
• Caused by OAB and BPH
• Too much 5-DHT
• Treated with tadalafil

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