Anti-Dysrhythmic Drugs

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Clues

• Unidirectional block and re-entry
• Avoid in narrow angle glaucoma
• Phase 4 (spontaneous depolarization)
• Broad spectrum, very long t1/2, lung toxicity
• Pharmacological conversion of Afib in hypothyroid patient
• Ventricular rate control - permanent A fib
• Moderate block Phase O, cinchonism
• Epinephrine i.v., i.o.*, e.t.t.+,
• Increase AV conduction velocity, treats AV block
• Class III and IA MOA (long QT)
• Increased automaticity
• SLE-like syndrome, slow acetylator
• i.v. very short t1/2 (secs), avoid in cardiac transplant
• Torsade de pointes (IKr)
• Class 1B, i.v., ventricular tachycardia
• Digoxin-induced arrhythmia
• Potential to worsen WPW, syndrome
• Decrease levels if diltiazemy propafeuone, propranolol
• Stroke prevention in Afib
• B-AR and K+ channel blocker

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